{"id":294,"date":"2014-02-07T08:00:07","date_gmt":"2014-02-07T14:00:07","guid":{"rendered":"https:\/\/www.ulprospector.com\/knowledge\/?p=294"},"modified":"2022-05-31T14:19:55","modified_gmt":"2022-05-31T20:19:55","slug":"pcc-benefits-niacinamide","status":"publish","type":"post","link":"https:\/\/ulprospector.ul.com\/294\/pcc-benefits-niacinamide\/","title":{"rendered":"The Benefits of Niacinamide"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-296\" src=\"https:\/\/ulprospector.ul.com\/media\/2013\/12\/Screen-Shot-2013-12-12-at-4.17.34-PM-300x227.png\" alt=\"Niacinamide b3\" width=\"300\" height=\"227\" srcset=\"https:\/\/ulprospector.ul.com\/wp-content\/uploads\/2013\/12\/Screen-Shot-2013-12-12-at-4.17.34-PM-300x227.png 300w, https:\/\/ulprospector.ul.com\/wp-content\/uploads\/2013\/12\/Screen-Shot-2013-12-12-at-4.17.34-PM.png 665w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><a href=\"http:\/\/www.ulprospector.com\/en\/na\/PersonalCare\/search?incival=4294963511&amp;sug=1&amp;st=31\" target=\"_blank\" rel=\"noopener\">Niacinamide<\/a> is a multifunctional active whose efficacy has been substantiated in numerous peer-reviewed journals. This biologically active form of niacin (<a href=\"http:\/\/www.ulprospector.com\/en\/na\/PersonalCare\/search?k=vitamin+b3&amp;st=31\" target=\"_blank\" rel=\"noopener\">vitamin B3<\/a>) is found widely in many plants and animals.<\/p>\n<p>It is also an important precursor to the co-factors NADH (Nicotinamide Adenine Dinucleotide) and NADPH (Nicotinamide Adenine Dinucleotide Phosphate). Along with their reduced forms NADH and NADPH, they act as coenzymes in more than 40 biochemical reactions and can also act as antioxidants.<\/p>\n<p>Niacinamide is a water soluble material that is solution and light stable. The optimum solution stability is at a PH 6. It can hydrolyze and form nicotinic acid at higher or lower PH, which can result in skin irritation.<\/p>\n<h3>Benefits<\/h3>\n<h4>Improved Skin Barrier Function<\/h4>\n<ul>\n<li>Topical Niacinamide increases free fatty acid ceramide levels in the skin, stimulates micro-circulation in the dermis, and prevents the skin from losing water. It also increases protein synthesis (e.g. keratin), raises intracellular NADP levels, and speeds up the differentiation of keratinocytes.<\/li>\n<\/ul>\n<h4>Anti-Aging<\/h4>\n<ul>\n<li>5% Topical Niacinamide reduces wrinkling, red blotchiness, yellowing and hyper pigmented spots in aging facial skin.<\/li>\n<li>Synergy with Kinetin is claimed.<\/li>\n<li>Senetek claims that a combination of Kinetin and niacinamide may reduce facial wrinkles in Asian women by nearly 50%.<\/li>\n<\/ul>\n<h4>Moisturization<\/h4>\n<ul>\n<li>In a small study, 2% topical Niacinamide shown to be more effective than Vaseline (petrolatum) for reducing skin water loss and increasing hydration.<\/li>\n<\/ul>\n<h4>Reduced Skin Oiliness<\/h4>\n<ul>\n<li>2% Niacinamide topically applied may be effective in reducing sebum production. Synergy with Sodium Dehydroacetic acid is claimed.<\/li>\n<\/ul>\n<h4>Reduced Skin Pore Size<\/h4>\n<ul>\n<li>Synergy with Sodium Dehydroacetic acid is claimed.<\/li>\n<\/ul>\n<h4>Improved Rosacea<\/h4>\n<h4>Reduced Hyperkeratosis<\/h4>\n<h4>Acne<\/h4>\n<ul>\n<li>4% Nicotinamide gel is comparable in efficacy to 1% clindamycin gel (leading topical prescription for treating acne) in the treatment of acne vulgaris.<\/li>\n<\/ul>\n<h4>Skin Lightening<\/h4>\n<ul>\n<li>Niacinamide is believed to influence cutaneous pigmentation by down-regulating transfer of Melanosomes from Melanocytes to the Keratinocytes without inhibiting tyrosinase activity or cell proliferation, and it may also interfere with the cell-signaling pathway between Keratinocytes and Melanocytes to decrease melanogenesis.<\/li>\n<li>Topical 2 to 5% Niacinamide has shown some efficacy when used alone or in combination with N-Acetyl Glucosamine for the treatment of melasma and UV-induced hyperpigmentation in fair-skinned patients and Asians. Synergy with N Acetyl Glucosamine is claimed.<\/li>\n<li>Niacinamide with Retinyl Palmitate has been shown to improve hyperpigmentation and increase skin lightening after 4 weeks of treatment compared with vehicle alone.<\/li>\n<\/ul>\n<h3>References<\/h3>\n<p>1. Niren. NM Pharmacologic doses of Nicotinamide In the treatment of Inflammatory skin conditions: a review. Cutis (Jan. 2006), 77(1 Suppl):11-6.<\/p>\n<p>2. Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical Nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int. J. Dermato.34 (6): 434-7.<\/p>\n<p>3. Hakozaki T, Mlnwalla L Zhuang J el al. The effect of Niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br. J Dermatol. (July 2002), 147 (1): 20-31.<\/p>\n<p>4. Gehring W. Nicotinic acid\/Niacinamide and the skin. Journal of Cosmetic Dermatology (2004) 3 (2), 88\u201393.<\/p>\n<p>5. Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK., Department of Dermatology, State University of New York, College of Medicine, Brooklyn, USA.<\/p>\n<p>6. Navarrete-Sol\u00eds J, Castanedo-C\u00e1zares JP, Torres-\u00c1lvarez B, Oros-Ovalle C, Fuentes-Ahumada C, Gonz\u00e1lez FJ, Mart\u00ednez-Ram\u00edrez JD, Moncada B. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatol Res Pract. 2011:379173.<\/p>\n<p>7. Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M. Moisturizing effects of topical Nicotinamide on atopic dry skin. Int. J. Dermato., March 2005, 197-202.<\/p>\n<p>8. Bissett, D. L.; Miyamoto, K.; Sun, P.; Li, J.; Berge, C. A. Topical Niacinamide reduces yellowing, wrinkling, red blotchiness, and hyper pigmented spots in aging facial skin. Int. J. Cosmet. Sci., Vol. 26, Number 5, Oct. 2004, 231-238.<\/p>\n<p>9. US 5980921 Topical compositions for regulating the oily\/shiny appearance of skin (Procter and Gamble-11\/9\/99).<\/p>\n<p>10. EP 0896522B1 Methods of regulating skin appearance with vitamin B3 compound (Procter and Gamble-4\/23\/97).<\/p>\n<p>11. Draelos ZD, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis. 2005 Aug; 76(2):135-41.<\/p>\n<p>12. Chiu PC, Chan CC, Lin HM, Chiu HC, The clinical anti-aging effects of topical Kinetin and Niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J. Cosmet. Dermatol. 2007 Dec: 6(4):243-9.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Niacinamide is a multifunctional active whose efficacy has been substantiated in numerous peer-reviewed journals. This biologically active form of niacin (vitamin B3) is found widely in many plants and animals. It is also an important precursor to the co-factors NADH &hellip; <a href=\"https:\/\/ulprospector.ul.com\/294\/pcc-benefits-niacinamide\/\">Continued<\/a><\/p>\n","protected":false},"author":6,"featured_media":295,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","footnotes":""},"categories":[5],"tags":[],"ppma_author":[1251],"class_list":{"0":"post-294","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-personal-care-cosmetics-cleaners","8":"entry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Benefits of Niacinamide | Innovadex<\/title>\n<meta name=\"description\" content=\"Expert personal care formulator George Deckner discusses the benefits of niacinamide, or vitamin b3, in skin care formulations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ulprospector.ul.com\/294\/pcc-benefits-niacinamide\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Benefits of Niacinamide | Innovadex\" \/>\n<meta property=\"og:description\" content=\"Expert personal care formulator George Deckner discusses the benefits of niacinamide, or vitamin b3, in skin care formulations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ulprospector.ul.com\/294\/pcc-benefits-niacinamide\/\" \/>\n<meta property=\"og:site_name\" content=\"Prospector Knowledge Center\" \/>\n<meta property=\"article:published_time\" content=\"2014-02-07T14:00:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-05-31T20:19:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ulprospector.ul.com\/wp-content\/uploads\/2013\/12\/Niacinamide.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"496\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"George Deckner\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"George Deckner\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/294\\\/pcc-benefits-niacinamide\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/294\\\/pcc-benefits-niacinamide\\\/\"},\"author\":{\"name\":\"George Deckner\",\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/#\\\/schema\\\/person\\\/4e8c804f4d62b747a0827fe8a3456717\"},\"headline\":\"The Benefits of Niacinamide\",\"datePublished\":\"2014-02-07T14:00:07+00:00\",\"dateModified\":\"2022-05-31T20:19:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/294\\\/pcc-benefits-niacinamide\\\/\"},\"wordCount\":667,\"image\":{\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/294\\\/pcc-benefits-niacinamide\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ulprospector.ul.com\\\/wp-content\\\/uploads\\\/2013\\\/12\\\/Niacinamide.jpg\",\"articleSection\":[\"Personal Care &amp; 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His rich professional background in innovative product development, research, material science and exploratory formulation, as well as a passion for developing products that make people\u2019s lives more comfortable and happy, inform the articles he writes for Knowledge.ULProspector.com. In addition to lending his industry expertise to Prospector, George consults with personal care and cosmetics suppliers. He founded his consulting practice, Deckner Consulting Services, after retiring from Procter &amp; Gamble in 2013, where he was a Victor Miles Research Fellow. While at Procter and Gamble, he worked in skin care product development, global fragrance development, and most recently oral care product development in the Oral Care Advanced Technology Innovation Group. Before being appointed a Victor Miles Research Fellow, he also served as Associate Director of Exploratory Formulation for skin care product development. While at Procter &amp; Gamble, George was one of the top inventors, with 354 granted and filed global patents (201 U.S. patents). He helped develop many of the core platform technologies used in skin care today with numerous products commercialized under the Olay, Bain de Soleil, Clearasil, Noxzema and SK2 brands. Previously, George was a Senior Chemist and Manager in the area of skin care product development, as well as the Director of Exploratory Formulation for Charles of the Ritz Group. During this time, George received the President\u2019s Cup Award for outstanding business contribution and developed numerous marketed skin care products under the Bain de Soleil, Jean Nate, Yves Saint Laurent and Charles of the Ritz Brands. George is a current member of the Society of Cosmetic Chemists and is on the scientific advisory board for Cosmetics &amp; Toiletries Magazine. He is a frequent guest lecturer for numerous key global suppliers, as well as for local and national SCC meetings. 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His rich professional background in innovative product development, research, material science and exploratory formulation, as well as a passion for developing products that make people\u2019s lives more comfortable and happy, inform the articles he writes for Knowledge.ULProspector.com. In addition to lending his industry expertise to Prospector, George consults with personal care and cosmetics suppliers. He founded his consulting practice, Deckner Consulting Services, after retiring from Procter &amp; Gamble in 2013, where he was a Victor Miles Research Fellow. While at Procter and Gamble, he worked in skin care product development, global fragrance development, and most recently oral care product development in the Oral Care Advanced Technology Innovation Group. Before being appointed a Victor Miles Research Fellow, he also served as Associate Director of Exploratory Formulation for skin care product development. While at Procter &amp; Gamble, George was one of the top inventors, with 354 granted and filed global patents (201 U.S. patents). He helped develop many of the core platform technologies used in skin care today with numerous products commercialized under the Olay, Bain de Soleil, Clearasil, Noxzema and SK2 brands. Previously, George was a Senior Chemist and Manager in the area of skin care product development, as well as the Director of Exploratory Formulation for Charles of the Ritz Group. During this time, George received the President\u2019s Cup Award for outstanding business contribution and developed numerous marketed skin care products under the Bain de Soleil, Jean Nate, Yves Saint Laurent and Charles of the Ritz Brands. George is a current member of the Society of Cosmetic Chemists and is on the scientific advisory board for Cosmetics &amp; Toiletries Magazine. He is a frequent guest lecturer for numerous key global suppliers, as well as for local and national SCC meetings. George is an avid tennis player and follower of the sport. He lives in Cincinnati, Ohio. Learn more about Deckner Consulting Services...","sameAs":["https:\/\/ulprospector.ul.com"],"url":"https:\/\/ulprospector.ul.com\/author\/george-deckner\/"}]}},"authors":[{"term_id":1251,"user_id":6,"is_guest":0,"slug":"george-deckner","display_name":"George Deckner","avatar_url":"https:\/\/ulprospector.ul.com\/media\/2017\/10\/George-Deckner_avatar_1508792845-96x96.jpg","0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts\/294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/comments?post=294"}],"version-history":[{"count":0,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts\/294\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/media\/295"}],"wp:attachment":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/media?parent=294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/categories?post=294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/tags?post=294"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/ppma_author?post=294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}