{"id":499,"date":"2014-05-09T08:00:32","date_gmt":"2014-05-09T13:00:32","guid":{"rendered":"https:\/\/www.ulprospector.com\/knowledge\/?p=499"},"modified":"2016-04-12T09:22:39","modified_gmt":"2016-04-12T15:22:39","slug":"pcc-molecular-encapsulation-cyclodextrin","status":"publish","type":"post","link":"https:\/\/ulprospector.ul.com\/499\/pcc-molecular-encapsulation-cyclodextrin\/","title":{"rendered":"Molecular Encapsulation Using Cyclodextrin"},"content":{"rendered":"<figure id=\"attachment_506\" class=\"thumbnail wp-caption alignright\" style=\"width: 300px\"><a href=\"https:\/\/ulprospector.ul.com\/media\/2014\/05\/Cyclodextrin.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-506 size-medium\" src=\"https:\/\/ulprospector.ul.com\/media\/2014\/05\/Cyclodextrin-300x186.jpg\" alt=\"The three types of cyclodextrins.\" width=\"300\" height=\"186\" srcset=\"https:\/\/ulprospector.ul.com\/wp-content\/uploads\/2014\/05\/Cyclodextrin-300x186.jpg 300w, https:\/\/ulprospector.ul.com\/wp-content\/uploads\/2014\/05\/Cyclodextrin.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"caption wp-caption-text\">The three types of cyclodextrins. Click to view larger image.<\/figcaption><\/figure>\n<p><a href=\"http:\/\/www.ulprospector.com\/en\/na\/PersonalCare\/search?k=Cyclodextrins&amp;st=31\" target=\"_blank\">Cyclodextrins<\/a>\u00a0(<a href=\"http:\/\/www.ulprospector.com\/en\/eu\/PersonalCare\/search?k=Cyclodextrins&amp;st=31\" target=\"_blank\">EU<\/a>), or CDs, are cyclic oligosaccharides with a defined ring size that are used in foods, cosmetics, home care products, and pharmaceuticals for active encapsulation and delivery. There are three basic types of natural CDs (alpha, beta, and gamma), which are produced from starch by enzymatic conversion. The bucket-shaped molecule has a hydrophilic exterior and a hydrophobic cavity and is able to form inclusion complexes with many organic guest compounds.<\/p>\n<p>Alpha has the smallest cavity, gamma the largest, and beta has an intermediate size. Alpha works the best with low MW materials and gamma for those with high MW. C log P and molecular weight usually determine which CD will form the best complex with the highest binding constant. Complexation and release mainly depend on temperature and moisture conditions.\u00a0Beta CD is the most frequently used CD. It has a water solubility of 1.9% and is normally used to make insoluble complexes. <a href=\"http:\/\/www.ulprospector.com\/en\/na\/PersonalCare\/search?k=Hydroxypropyl&amp;st=31\" target=\"_blank\">Hydroxypropyl<\/a>\u00a0(<a href=\"http:\/\/www.ulprospector.com\/en\/eu\/Coatings\/search?k=Hydroxypropyl&amp;st=31\" target=\"_blank\">EU<\/a>) Beta Cyclodextrin is typically used to form water soluble complexes.<\/p>\n<h4>Applications of Cyclodextrins<\/h4>\n<ul>\n<li>Increased solubility and bioavailability of actives.<\/li>\n<li>Reduced <a href=\"http:\/\/www.ulprospector.com\/en\/na\/PersonalCare\/search?k=volatility&amp;st=31\" target=\"_blank\">volatility<\/a>\u00a0(<a href=\"http:\/\/www.ulprospector.com\/en\/eu\/PersonalCare\/search?k=volatility&amp;st=31\" target=\"_blank\">EU<\/a>).<\/li>\n<li>Stabilization of actives (light, oxidation, temperature).<\/li>\n<li>Selective extraction (Cholesterol).<\/li>\n<li>Taste masking.<\/li>\n<li>Odor control.<\/li>\n<li>Extended release of fragrances, flavors, and <a href=\"http:\/\/www.ulprospector.com\/en\/na\/PersonalCare\/search?k=antimicrobials&amp;st=31\" target=\"_blank\">antimicrobials<\/a>\u00a0(<a href=\"http:\/\/www.ulprospector.com\/en\/eu\/PersonalCare\/search?k=antimicrobials&amp;st=31\" target=\"_blank\">EU<\/a>).<\/li>\n<li>Moisture-triggered release.<\/li>\n<li>Making Pickering emulsions.<\/li>\n<\/ul>\n<h4>Commercially Available CDs<\/h4>\n<ul>\n<li>Hydroxypropyl alpha, beta, and gamma cyclodextrins.<\/li>\n<li>Methylated beta cyclodextrin.<\/li>\n<li>Alpha, beta, and gamma cyclodextrins.<\/li>\n<\/ul>\n<h4>Procedure for Making Insoluble Complexes<\/h4>\n<ul>\n<li>Make an aqueous slurry containing 40% beta Cyclodextrin (BCD) and 56% water. Add 4% active and mix for an hour. You can heat the slurry or dissolve the active in a water soluble solvent to help facilitate complexation. Spread slurry on pan and dry. Grind dried powder to reduce particle size.<\/li>\n<li>Most complexes are 1 to 1 or 1 to 2\u00a0active\/BCD on a molar basis. A 1 to 10 ratio on a weight basis active\/BCD is normally a good starting point<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Cyclodextrins\u00a0(EU), or CDs, are cyclic oligosaccharides with a defined ring size that are used in foods, cosmetics, home care products, and pharmaceuticals for active encapsulation and delivery. There are three basic types of natural CDs (alpha, beta, and gamma), which &hellip; <a href=\"https:\/\/ulprospector.ul.com\/499\/pcc-molecular-encapsulation-cyclodextrin\/\">Continued<\/a><\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","footnotes":""},"categories":[5],"tags":[],"ppma_author":[1251],"class_list":{"0":"post-499","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-personal-care-cosmetics-cleaners","7":"entry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Molecular Encapsulation Using Cyclodextrin - Prospector Knowledge Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ulprospector.ul.com\/499\/pcc-molecular-encapsulation-cyclodextrin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular Encapsulation Using Cyclodextrin - Prospector Knowledge Center\" \/>\n<meta property=\"og:description\" content=\"Cyclodextrins\u00a0(EU), or CDs, are cyclic oligosaccharides with a defined ring size that are used in foods, cosmetics, home care products, and pharmaceuticals for active encapsulation and delivery. There are three basic types of natural CDs (alpha, beta, and gamma), which &hellip; Continued\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ulprospector.ul.com\/499\/pcc-molecular-encapsulation-cyclodextrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Prospector Knowledge Center\" \/>\n<meta property=\"article:published_time\" content=\"2014-05-09T13:00:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2016-04-12T15:22:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ulprospector.ul.com\/media\/2014\/05\/Cyclodextrin-300x186.jpg\" \/>\n<meta name=\"author\" content=\"George Deckner\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"George Deckner\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/499\\\/pcc-molecular-encapsulation-cyclodextrin\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/499\\\/pcc-molecular-encapsulation-cyclodextrin\\\/\"},\"author\":{\"name\":\"George Deckner\",\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/#\\\/schema\\\/person\\\/4e8c804f4d62b747a0827fe8a3456717\"},\"headline\":\"Molecular Encapsulation Using Cyclodextrin\",\"datePublished\":\"2014-05-09T13:00:32+00:00\",\"dateModified\":\"2016-04-12T15:22:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/499\\\/pcc-molecular-encapsulation-cyclodextrin\\\/\"},\"wordCount\":320,\"commentCount\":1,\"image\":{\"@id\":\"https:\\\/\\\/ulprospector.ul.com\\\/499\\\/pcc-molecular-encapsulation-cyclodextrin\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ulprospector.ul.com\\\/media\\\/2014\\\/05\\\/Cyclodextrin-300x186.jpg\",\"articleSection\":[\"Personal Care &amp; 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His rich professional background in innovative product development, research, material science and exploratory formulation, as well as a passion for developing products that make people\u2019s lives more comfortable and happy, inform the articles he writes for Knowledge.ULProspector.com. In addition to lending his industry expertise to Prospector, George consults with personal care and cosmetics suppliers. He founded his consulting practice, Deckner Consulting Services, after retiring from Procter &amp; Gamble in 2013, where he was a Victor Miles Research Fellow. While at Procter and Gamble, he worked in skin care product development, global fragrance development, and most recently oral care product development in the Oral Care Advanced Technology Innovation Group. Before being appointed a Victor Miles Research Fellow, he also served as Associate Director of Exploratory Formulation for skin care product development. While at Procter &amp; Gamble, George was one of the top inventors, with 354 granted and filed global patents (201 U.S. patents). He helped develop many of the core platform technologies used in skin care today with numerous products commercialized under the Olay, Bain de Soleil, Clearasil, Noxzema and SK2 brands. Previously, George was a Senior Chemist and Manager in the area of skin care product development, as well as the Director of Exploratory Formulation for Charles of the Ritz Group. During this time, George received the President\u2019s Cup Award for outstanding business contribution and developed numerous marketed skin care products under the Bain de Soleil, Jean Nate, Yves Saint Laurent and Charles of the Ritz Brands. George is a current member of the Society of Cosmetic Chemists and is on the scientific advisory board for Cosmetics &amp; Toiletries Magazine. He is a frequent guest lecturer for numerous key global suppliers, as well as for local and national SCC meetings. George is an avid tennis player and follower of the sport. He lives in Cincinnati, Ohio. Learn more about Deckner Consulting Services...\",\"sameAs\":[\"https:\\\/\\\/ulprospector.ul.com\"],\"url\":\"https:\\\/\\\/ulprospector.ul.com\\\/author\\\/george-deckner\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Molecular Encapsulation Using Cyclodextrin - Prospector Knowledge Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ulprospector.ul.com\/499\/pcc-molecular-encapsulation-cyclodextrin\/","og_locale":"en_US","og_type":"article","og_title":"Molecular Encapsulation Using Cyclodextrin - Prospector Knowledge Center","og_description":"Cyclodextrins\u00a0(EU), or CDs, are cyclic oligosaccharides with a defined ring size that are used in foods, cosmetics, home care products, and pharmaceuticals for active encapsulation and delivery. 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His rich professional background in innovative product development, research, material science and exploratory formulation, as well as a passion for developing products that make people\u2019s lives more comfortable and happy, inform the articles he writes for Knowledge.ULProspector.com. In addition to lending his industry expertise to Prospector, George consults with personal care and cosmetics suppliers. He founded his consulting practice, Deckner Consulting Services, after retiring from Procter &amp; Gamble in 2013, where he was a Victor Miles Research Fellow. While at Procter and Gamble, he worked in skin care product development, global fragrance development, and most recently oral care product development in the Oral Care Advanced Technology Innovation Group. Before being appointed a Victor Miles Research Fellow, he also served as Associate Director of Exploratory Formulation for skin care product development. While at Procter &amp; Gamble, George was one of the top inventors, with 354 granted and filed global patents (201 U.S. patents). He helped develop many of the core platform technologies used in skin care today with numerous products commercialized under the Olay, Bain de Soleil, Clearasil, Noxzema and SK2 brands. Previously, George was a Senior Chemist and Manager in the area of skin care product development, as well as the Director of Exploratory Formulation for Charles of the Ritz Group. During this time, George received the President\u2019s Cup Award for outstanding business contribution and developed numerous marketed skin care products under the Bain de Soleil, Jean Nate, Yves Saint Laurent and Charles of the Ritz Brands. George is a current member of the Society of Cosmetic Chemists and is on the scientific advisory board for Cosmetics &amp; Toiletries Magazine. He is a frequent guest lecturer for numerous key global suppliers, as well as for local and national SCC meetings. George is an avid tennis player and follower of the sport. He lives in Cincinnati, Ohio. Learn more about Deckner Consulting Services...","sameAs":["https:\/\/ulprospector.ul.com"],"url":"https:\/\/ulprospector.ul.com\/author\/george-deckner\/"}]}},"authors":[{"term_id":1251,"user_id":6,"is_guest":0,"slug":"george-deckner","display_name":"George Deckner","avatar_url":"https:\/\/ulprospector.ul.com\/media\/2017\/10\/George-Deckner_avatar_1508792845-96x96.jpg","0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts\/499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/comments?post=499"}],"version-history":[{"count":0,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts\/499\/revisions"}],"wp:attachment":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/media?parent=499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/categories?post=499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/tags?post=499"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/ppma_author?post=499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}