{"id":6261,"date":"2017-04-07T08:00:13","date_gmt":"2017-04-07T14:00:13","guid":{"rendered":"https:\/\/www.ulprospector.com\/knowledge\/?p=6261"},"modified":"2018-01-04T16:10:52","modified_gmt":"2018-01-04T22:10:52","slug":"pcc-antiperspirants-and-breast-cancer-a-lingering-legend","status":"publish","type":"post","link":"https:\/\/ulprospector.ul.com\/6261\/pcc-antiperspirants-and-breast-cancer-a-lingering-legend\/","title":{"rendered":"Antiperspirants and Breast Cancer: A Lingering Legend"},"content":{"rendered":"<figure id=\"attachment_6262\" class=\"thumbnail wp-caption alignright\" style=\"width: 300px\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/ulprospector.ul.com\/media\/2017\/04\/10349256_600400-300x200.jpg\" alt=\"Are antiperspirants linked to breast cancer? Are aluminum salts to blame? Priscilla Taylor offers an overview of what research reveals.\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Copyright: <a href=\"https:\/\/www.123rf.com\/profile_mtoome\">mtoome \/ 123RF Stock Photo<\/a><\/figcaption><\/figure>\n<p>Despite the many studies that have refuted rumors that antiperspirants are linked to breast cancer, these stories are still being perpetuated today. I was reminded of this recently when a family member shared this rumor with much conviction, having heard it from her hairstylist.\u00a0 The intent of this article is to provide the reader with a synopsis of some of the relevant research on this topic. I hope that this will arm you with an informed response when confronted by an ardent proponent.<\/p>\n<p>First, some basic information: Antiperspirants are classified as over-the-counter drugs by the Food and Drug Administration (FDA) and a monograph has been established that provides guidelines for meeting this classification \u2013 <a href=\"https:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/developmentresources\/over-the-counterotcdrugs\/statusofotcrulemakings\/ucm110774.pdf\">FDA\u2019s OTC antiperspirant monograph<\/a>. The monograph specifies various aluminum salts that can be used as the active ingredients in antiperspirants. Those most commonly used in contemporary antiperspirant formulations include Aluminum Chlorohydrate, Aluminum Tetrachlorohydrex GLY and Aluminum Trichlorohydrex GLY.<\/p>\n<p><strong>Aluminum salts<\/strong> react with moisture on the skin to form a \u2018plug\u2019 which temporarily blocks sweat glands and helps reduce perspiration. One hypothesis that supports the link between antiperspirants and breast cancer is that the formation of these \u2018plugs\u2019 prevent the body from purging toxins, which then collect in the lymph nodes, eventually causing cellular changes that lead to cancer. This was addressed in an article published by the American Cancer Society<sup>1<\/sup>, which explained that lymph nodes do not excrete toxins through sweating since they are not connected to sweat glands.<\/p>\n<p>At the heart of the claim that antiperspirant use elevates the risk of breast cancer is that aluminum salts are capable of penetrating the axillary vault, accumulating in breast cells, where they effect change that eventually leads to cancer.\u00a0 Dermal absorption of aluminum has been investigated. Results indicate that there is minimal absorption into healthy skin, with one study reporting that 0.012% of the applied aluminum was absorbed<sup>2. <\/sup><\/p>\n<p>However, another study found that aluminum uptake increased in compromised skin<sup>3<\/sup>. \u00a0These results then raise the question of whether the combination of frequent underarm shaving and antiperspirant use increases the risk of breast cancer. This does not seem to be the case based on the results of a study which found that the risk of breast cancer did not increase among subjects who shaved<sup>4<\/sup>.<\/p>\n<h3>Working on an antiperspirant formulation?<\/h3>\n<p>Prospector has more than 400 listings for antiperspirant ingredients and formulations. Find technical information, order samples and more now&#8230;<\/p>\n<p><a href=\"https:\/\/www.ulprospector.com\/en\/na\/PersonalCare\/search?k=antiperspirant&amp;st=31\" target=\"_blank\" rel=\"noopener\"><br \/>\nClick Here<br \/>\n<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Since carcinomas are commonly found in the upper outer quadrant of the breast, this fact is used to support the hypothesis that aluminum-based underarm cosmetics are linked to breast cancer. Based on the results of a 2005 study<sup>5<\/sup>, it would appear that the frequency of occurrence in this region is most likely due to the greater amount of breast tissue in the upper outer quadrant &#8211; a conclusion also drawn by the American Cancer Society<sup>1<\/sup>. Proponents also speculate that nicks caused by underarm shaving create a pathway for aluminum salts to enter breast cells resulting in mutations that lead to cancer. This, too, has been refuted by the American Cancer Society<sup>1<\/sup>.<\/p>\n<p>Despite the body of scientific evidence that contradicts the notion that there is a link between antiperspirant use and breast cancer, skeptics remain unconvinced and questions persist. However, it is important to note that antiperspirants continue to be recognized as safe and effective for use by the FDA as well as major industry organizations.<\/p>\n<h3>References<\/h3>\n<ol>\n<li>Cancer.org: <a href=\"https:\/\/www.cancer.org\/cancer\/cancer-causes\/antiperspirants-and-breast-cancer-risk.html\">Antiperspirants and Breast Cancer Risk<\/a><\/li>\n<li>Flarend R, et al. A preliminary study of the dermal absorption of aluminum from antiperspirants using aluminum 26. Food and Chemical Toxicology. 2001 Feb; 39 (2) 163-8 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11267710\">Pub Med Abstract<\/a>)<\/li>\n<li>Pineau A, et al. In vitro study of percutaneous absorption of aluminum from antiperspirants through human skin in the Franz\u2122 diffusion cell. Journal of Inorganic Biochemistry, May 2012 Vol. 110:21-26 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22459170\">Pub Med Abstract<\/a>)<\/li>\n<li>Mirick DK, Davis S, Thomas DB. Antiperspirant use and the risk of breast cancer.<em> Journal of the National Cancer Institute<\/em>2002; 94(20):1578\u20131580. (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12381712\">Pub Med Abstract<\/a>)<\/li>\n<li>Lee AHS. Why is carcinoma of the breast more frequent in the upper outer quadrant? A case series based on needle core biopsy diagnoses. 2005;14:151\u2013152<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Despite the many studies that have refuted rumors that antiperspirants are linked to breast cancer, these stories are still being perpetuated today. I was reminded of this recently when a family member shared this rumor with much conviction, having heard &hellip; <a href=\"https:\/\/ulprospector.ul.com\/6261\/pcc-antiperspirants-and-breast-cancer-a-lingering-legend\/\">Continued<\/a><\/p>\n","protected":false},"author":5,"featured_media":6262,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","footnotes":""},"categories":[5],"tags":[236],"ppma_author":[1255],"class_list":{"0":"post-6261","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-personal-care-cosmetics-cleaners","8":"tag-material-overview","9":"entry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Antiperspirants and breast cancer: examining the chemistry and current research<\/title>\n<meta name=\"description\" content=\"Are antiperspirants linked to breast cancer? 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In this role, she provides invaluable insight by consulting on all matters related to the industry. Her significant contributions to site optimizations and ingredient classifications enhance user experience on ULProspector.com. Priscilla's expertise was developed during her 21 years as a product development professional. She began her career in the 90's at Helene-Curtis Industries in Chicago, where she discovered her passion for putting a product together from concept to completion. When Helene-Curtis was purchased by industry giant Unilever in 1996, Priscilla was promoted to Senior Product Development Manager. She had the privilege of working with global teams to develop and launch products both domestically and worldwide for many popular brands, including Dove and Suave. Concurrent to her work at Prospector, Priscilla is a Product Development Chemist with Bria Research Labs. She is actively involved in formulating for a diverse array of clients. While she mostly formulates personal care and cosmetics products, she has also had the opportunity to work on projects for the household, industrial and institutional cleaners industry. Priscilla was born and raised in Trinidad, West Indies, but she considers Chicago her adopted hometown. She lives there with her daughter, Jessica, and her Dachshund, Peanut, who assist her with her favorite pastime: cheering on Chicago's famed sports teams.","sameAs":["https:\/\/ulprospector.ul.com"],"url":"https:\/\/ulprospector.ul.com\/author\/priscilla-taylor\/"}]}},"authors":[{"term_id":1255,"user_id":5,"is_guest":0,"slug":"priscilla-taylor","display_name":"Priscilla Taylor","avatar_url":"https:\/\/ulprospector.ul.com\/media\/2017\/10\/Priscilla-Taylor_avatar_1508792435-96x96.jpg","0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts\/6261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/comments?post=6261"}],"version-history":[{"count":0,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/posts\/6261\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/media\/6262"}],"wp:attachment":[{"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/media?parent=6261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/categories?post=6261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/tags?post=6261"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/ulprospector.ul.com\/wp-json\/wp\/v2\/ppma_author?post=6261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}